Tuberculosis is still one of the deadliest infectious diseases, causing over one million deaths each year worldwide. Additionally, about one-fourth of the world's population carries Mycobacterium ...

The focus of vertebrate studies has mainly been on canonical phosphorylation, but research indicates that phosphorylation of other non-canonical amino acids also regulates integral aspects of cell ...

Post-translational modifications (PTMs) of protein molecules play a critical role in health and disease and drive the signaling within a cell. The ability to detect and discern these alterations could ...

Ubiquitination is a crucial post-translational modification process where the small protein ubiquitin is attached to target proteins, marking them for degradation or altering their function. This ...

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein binds the host cell surface receptor angiotensin-converting enzyme 2 (ACE2). It is a glycosylated protein and is a target ...

Tsukuba, Japan—Proteins are subject to post-translational chemical modifications that result in functional diversity. Methylation is one such modification that is generally believed to occur on lysine ...

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...