纵观整项研究，我们不仅看到了FOCAS这一强大工具的威力，更看到了它所揭示的生物学复杂性。过去针对m6A的抗癌策略往往类似于“地毯式轰炸”（如全局抑制METTL3或FTO），虽然有效，但伴随着破坏管家功能的风险。

A new study led by researchers at UTHealth Houston investigated both gene expression and regulation at single cell levels to ...

Scientists at the MRC Laboratory of Medical Sciences (LMS) have discovered a DNA-based “dimmer switch” that regulates the activity of a critical developmental gene, Cdx2. This work could pave the way ...

Precision and timing of gene expression is essential for normal biological functions and, when disrupted, can lead to many ...

We know the genes, but not their functions—to resolve this long-standing bottleneck in microbial research, a joint research ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

As we age, we don't recover from injury or illness like we did when we were young. But new research from UCSF has found gene ...

Inducible promoters provide remarkable utility when sustained transgene expression compromises plant development or agronomic performance. In this study, four different plant heat shock protein (HSP) ...

What do your genes have to do with growing old? Quite a lot. But is it due to the actual DNA, or the way those genes are expressed? KPBS sci-tech reporter Thomas Fudge has more on new research that ...

PCR-based techniques have transformed how scientists analyze transcripts’ translational applications in cancer and ...