核酸适配体（Aptamer）是一类短的单链 DNA 或 RNA 寡核苷酸，通过形成三维空间结构，靶向结合特定蛋白或者细胞发挥作用，其具有广泛优点，包括高度特异性、易于合成、可定制、热稳定性好、分子小、组织穿透能力强等。成为选择性靶向特定蛋白质或细胞以治疗多种疾病类型的新选择。

This important study, which tackles the challenge of analyzing genome integrity and instability in unicellular pathogens by introducing a novel single-cell genomics approach, presents compelling ...

A research team led by Zhiping Weng, Ph.D., and Jill Moore, Ph.D."18, at UMass Chan Medical School, has nearly tripled the ...

食管鳞癌（ESCC）占食管癌90%，早期治疗依赖内镜切除，但复发率高，缺乏特异靶向药物。液-液相分离（LLPS）在肿瘤中的作用日益受关注，但与ESCC关系不明。

基因编辑，特别是最新的碱基编辑技术，能像“分子铅笔”一样直接改写DNA上的单个字母（碱基），理论上比直接切断DNA的Cas9更安全、精准。但“脱靶”问题始终如影随形。准确找出所有脱靶位点，如同在茫茫基因组中寻找几个拼写错误，极其困难。

The new technique is called CLASSIC, an acronym for “combining long and short range sequencing to investigate genetic ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

The collection of high-quality genomic DNA remains a major barrier in pediatric and neurodevelopmental research, particularly ...

The global DNA methylation market size was valued at US$ 1.9 Bn in 2025 and is projected to reach US$ 7.7 Bn by 2036, growing ...

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...